Funny, impatient and politically incorrect, MINDY LAHIRI (Kaling) can quote every romantic comedy starring Meg Ryan that exists. She loves the good ones and the bad ones, because the girl always gets the guy. Mindy is determined to be more punctual, spend less money, lose weight and read more books - all in pursuit of becoming a well-rounded perfect woman...who can meet and date the perfect guy.
Despite her hectic personal life, Mindy is a skilled OB/GYN and shares a practice with a few other doctors, none of whom makes life any easier for her. DANNY CASTELLANO (Chris Messina) is a hothead and guys' guy who has a habit of stealing Mindy's patients. Danny criticizes her for everything, including her struggling love life and her lack of professionalism - even though it's obvious to everyone except Mindy that he secretly admires her work. In contrast, JEREMY REED (Ed Weeks) is the walking definition of total bad news. He not only shares a practice with Mindy, but sometimes her bed as well - despite her best efforts to resist. Male nurse MORGAN TOOKERS (Ike Barinholtz), a reformed ex-con and the hospital's resident cheerleader, just wishes that he and his colleagues spent more time together outside of work, while DR. SHULMAN (Stephen Tobolowsky), the head of the practice, is always excited to wax philosophical, especially if his advice gets the younger staff to leave him alone.
Rounding out the medical staff are the receptionists - BETSY PUTCH (Zoe Jarman), young, earnest and easily excitable, who thinks the world of Mindy and is always trying to impress her; and SHAUNA DICANIO (Amanda Setton), a self-assured Jersey Girl who is indifferent to Mindy, always knows where the cool party is and carries a poorly concealed torch for Danny. Mindy also is in constant contact with her sometimes too-blunt best friend from college, GWEN GRANDY (Anna Camp), a lawyer-turned-Pilates mom who happens to be the governor's daughter.
As Mindy attempts to get her career off the ground and meet a guy who passes her red flag test (no drug habits, no skinny jeans and no secret families, among others), only time will tell if she gets her romantic comedy ending.